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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

And it provides the medium where bacteria can grow, introducing biological contamination on top of chemical degradation

The liposomes were washed twice and finally suspended in phosphate buffered KCl (150 mM, 8 mL)

After filtering for quality, 36 studies met inclusion criteria for detailed analysis

Choi BY, Jung JW, Suh SW